Lysophosphatidic acid (LPA) 是一种内源性的甘油磷脂信号分子，也是EDG-2和EDG-4（LPA）受体的配体激活剂。据报道，与Lysophosphatidic acid相关的信号刺激成纤维细胞、血管平滑肌细胞、内皮细胞和角质细胞的生长。Lysophosphatidic Acid 被指示为既是增殖因子又是抗凋亡因子，发出Pl3K介导的细胞活性调节的信号。Lysophosphatidic Acid还被描述为通过G蛋白介导的激活Ca2+依赖/非依赖的蛋白激酶C来增强乙酰胆碱受体电流。Lysophosphatidic Acid 可以与四种G蛋白偶联受体中的一种结合，介导各种生物学反应，包括平滑肌收缩、细胞增殖、神经突触回缩和血小板聚集。
Lysophosphatidic Acid (CAS 325465-93-8) 参考文献溶血磷脂酸的合成与释放 | Pagès, C., et al. 2001. Prostaglandins Other Lipid Mediat. 64: 1-10. PMID: 11324699溶血磷脂酸在癌症中的新作用。 | Mills, GB. and Moolenaar, WH. 2003. Nat Rev Cancer. 3: 582-91. PMID: 12894246溶血磷脂酸的生成机制 | Aoki, J. 2004. Semin Cell Dev Biol. 15: 477-89. PMID: 15271293GPR92 是一种新的 G12/13- 和 Gq- 偶联溶血磷脂酸受体，可增加 cAMP 和 LPA5。 | Lee, CW., et al. 2006. J Biol Chem. 281: 23589-97. PMID: 16774927产生溶血磷脂酸的两条途径 | Aoki, J., et al. 2008. Biochim Biophys Acta. 1781: 513-8. PMID: 18621144新型溶血磷脂酸受体 p2y5/LPA6 的鉴定与表征 | Yanagida, K., et al. 2009. J Biol Chem. 284: 17731-41. PMID: 19386608针对溶血磷脂酸靶点进行药物研发。 | Tigyi, G. 2010. Br J Pharmacol. 161: 241-70. PMID: 20735414神经系统中的溶血磷脂酸信号传递。 | Yung, YC., et al. 2015. Neuron. 85: 669-82. PMID: 25695267发育过程中的溶血磷脂酸信号传导 | Sheng, X., et al. 2015. Development. 142: 1390-5. PMID: 25852197溶血磷脂酸，一种多功能磷脂信使。 | Moolenaar, WH. 1995. J Biol Chem. 270: 12949-52. PMID: 7768880溶血磷脂酸：肾近曲小管细胞的新型生长和存活因子 | Levine, JS., et al. 1997. Am J Physiol. 273: F575-85. PMID: 9362335溶血磷脂酸通过 G 蛋白介导的蛋白激酶 C 激活来增强 ACh 受体电流。 | Nishizaki, T. and Sumikawa, K. 1997. Brain Res Mol Brain Res. 50: 121-6. PMID: 9406926溶血磷脂酸是卵巢癌和其他妇科癌症的潜在生物标记物。 | Xu, Y., et al. 1998. JAMA. 280: 719-23. PMID: 9728644
抑制剂：ABR, DGK-ι, GOLT1A, GPR family (GPCR;G protein-coupled), MOB2, Rab 8A, SAV1, SUSD3, 和 WWC3.
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激活剂：α-protein kinase 1, αPAK, β1-Adaptin, βENaC, 1110032A03Rik, 1700001O22Rik, 1810030N24Rik, 2400001E08Rik, 3BP1, 4921501E09Rik, 4930432K09Rik, 4930549C01Rik, A430078G23Rik, ABHD2, ACBD5, Adducin γ, AFAP-1L2, Angptl1, ANKRD23, Annexin A10, ANXA2R, ANXA8L2, AP1S2, apoAL, ARAP1, Arg, ARHGAP25, ARHGEF18, ARHGEF19, ARHGEF33, ARHGEF37, ARHGEF39, ARHGEF5_Arhgef5, ARHGEF5L, Asp1, Astrotactin, Astrotactin 2, Aytl1b, AZI1, Baz, BIG2, BIN2, BLCAP, BLU, BRDG1, BSMAP, BST-1, c-Fgr, c-Src, C12orf48, C14orf166B, C17orf39_4933439F18Rik, C9orf30, CAGE, Cas-L, CCDC155, CCDC74B, CD1D, CD23, CD30L, CD36, CD88, CD97, Cdc42EP3, Cdc50B, CDCP1, CdGAP, Cdk6, Ceramide Kinase, CGNL1, CHMP4A, CIN85, Cks2, claudin-1, claudin-7, CLDN (Claudin), CLLD6, Clostridium difficile Toxin A, COBLL1, COL13A1, COL15A1, COL1A2, COL27A1, COL3A1, COL4A4, COL4A6, COL6A6, Collagen α2 Type VI, Cortisol, COX1, CXCL13, cyclin D3, CYTL1, D-type cyclin, D830046C22Rik, Dab1, DDR2, desmoglein 3, DIP2C, DIRAS2, Dkk-1, DNAH11, DnaJC12, DnaJC16, DNAJC25-GNG10, DOCK 10, DOCK 11, DOCK 5, Dok-5, Dokl, dolichol kinase, DOLPP1, ECM2, Ect2, EDG-2, EDG-4, EG436336, EG667512, EMILIN-2, EMR2, Ep-CAM, epsin2, ErbB-3, ERK 1, ETAA16, FAM13b, FAM57A, FBF1, Fbxo12, FGD2, FGD5, Fibulin-4, Filamin 3, FIT1, FRMD6, G β1, Gα 11, Gα 12, Gα 13, Gα i-1, Gα i-2, Gβ 3, Gγ 10, Gγ 11, G0S2, GAIP, GAL3ST2, galectin-3, gankyrin, GAPT, GCET2, GDE4, GDPD3, GDPD4, GEFT, GFRαL, GLTPD2, Gm216, GNB1L, GOLGA8R, GPR135, GPR137B, GPR141, GPR144, GPR34, GPR37L1, GPR56, GPR75, GPR87, GPR88, GPR92, GPRC5C, GRHL3, HAPLN3, HAPLN4, HemT-1, HIP3, IFT140, INDOL1, Influenza A m1, Integrin α10, Integrin β7, Integrin X, ITFG1, JAK2, JIP-1, JTB, KIAA1279, KIAA2013_2510039O18Rik, Kindlin-3, KIR5.1, KLK12, KLKBL4, KRTAP12-1, KRTAP12-2, L-Plastin, Lamellipodin, Laminin α-4, Laminin α-5, LANCL3, LAPTM4B, Lingo-1, LPAAT-β, LPAAT-γ, LPAAT-ζ, LPP, LPPR4, Ly-6K, Ly-GDI, LYPLA2, MAGP-1, MAGP-2, MAS1L, MEK-5, MEK2, MEK3, MFAP3, MFAP4, MKX, MMP-11, Mnk2, MOB1A, MOCA, MOSPD2, MPP7, MPP9, MTDH, Mucin 1, Mucin 17, Mucin 4, Myosin Ic, Myotrophin, NCK1, Nek10, Net, NET-4, NHE-3, Nidogen, Nir1, nm23-H1, NOR-1, NPWBP, Nucling, NWD1, OAT2, OCIL, Oculospanin, ORP-6, ORP-8, OSX, P4HA1, PAcP, PAP-2b, PATE2, paxillin, PC-PLD2, PC-PLD3, PCDH15_Pcdh15, PCDHA7, PDGFR-β, Peroxin 1, Peroxin 2, PI 3-kinase p85α, PI 4-kinase α, PI 4-kinase II α, PIG-Y, Pim-1, Pinch-1, PIPPIN, PLA1A, PLA2G4B, PLBD1, PLC β4, PLD, PLEKHG3, PLEKHG4B, plexin-A2, plexin-B1, plexin-B3, PLRG1, PNPLA7, podoplanin, POEM, Popeye 2, POPX2, PRAME like-1, PRELP, PREP-2, PRK1, Procollagen Type I, PSS1, PYK2, R-Ras, Rab 3B, Rab 44, Rab40B, Rac 1, Rag B, Rap 2B, RAPGEFL1, RASGEF1A, RASGEF1C, RGC32, RGD1562043, RGL1, RGS22, RHAMM, Rho A, Rho C, Rho D, Rho F, Rho G, Rho J, Rho T1, Rho V, RHOBTB1, Ribosomal Protein S25, RIC-8A, RIMKLB, RIN3, Rnd1, RNH1, Rock-1, Rock-2, SAMD8, SASPase, SDPR, SEMA4F, SEMA6B, SERINC1, SERINC4, SH2D4A, Sin, Slfn2, SMAP1L, SMG5, Soggy-1, Sphingomyelin Synthase 2, SphK1, SREB3, SRPX, SSc5D, StARD13, StARD9, Stat5a, Stat6, SUR-5, Syndecan-4, T-cadherin, Tβ-4 Y-linked, TBC1D26, TBC1D2B, TC 21, TC10, TDE2L, TEM5, Tenascin-X, Tensin3, TESK1, Testican-2, tetranectin, Thrombospondin 4, TIP-1, TLL1, TMEM184A, TMSL3, Tor1, tropoelastin, TSPAN1, TSPAN6, UBF, V-ATPase D2, V-ATPase F, vanin-2, versican, VgI-4, Vmn1r157, Vmn1r163, VPS13A, VPS4A, VPS4B, VPS51, VR1, VSIG6, WDR54, WDR62, WNK1, XKR6, XKR7, XKR9, Ypk2, ZBTB2, ZDHHC21, ZNF175, 和 ZXDA.
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